Publications

For citations and statistics, see Clarissa’s Google Scholar profile.

  1. Bakhtiary, A., Cochrane, S. A., Mercier, P., McKay, R. T., Miskolzie, M., Sit, C. S., Vederas, J. C. Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147. J. Am. Chem. Soc., 2017, 139, 17803-17810.

  2. Van Arnam, E. B., Ruzzini, A. C., Sit, C. S., Horn, H., Pinto-Tomás, A. A., Currie, C. R., Clardy, J. Selvamicin, an atypical antifungal polyene from two alternative genomic contexts. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 12940-12945.

  3. Lear, S., Munshi, T., Hudson, A. S., Hatton, C., Clardy, J., Mosely, J. A., Bull, T. J., Sit, C. S., Cobb, S. L. Total chemical synthesis of lassomycin and lassomycin-amide. Org. Biomol. Chem., 2016, 14, 4534-4541.

  4. Van Arnam, E. B., Ruzzini, A. C., Sit, C. S., Currie, C. R., Clardy, J. A rebeccamycin analog provides plasmid-encoded niche defense. J. Am. Chem. Soc., 2015, 137, 14272-14274.

  5. *Sit, C. S., *Ruzzini, A. C., Van Arnam, E. B., Ramadhar, T. R., Currie, C. R., Clardy, J. Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants. Proc. Natl. Acad. Sci. U. S. A. 2015, 112, 13150-13154. *The first and second authors contributed equally to this work.

  6. Cobb, S. L., Sit, C. S. Anti-infective peptides. In Advances in the discovery and development of peptide therapeutics; Kruger, G., Albericio, F., De Vooght-Johnson, R., Eds.; Future Science: London, 2014; Chapter 6, 96-110.

  7. *Gavrish, E., *Sit, C. S., Cao, S., Kandror, O., Spoering, A., Peoples, A., Ling, L., Fetterman, A., Hughes, D., Bissell, A., Torrey, H., Akopian, T., Mueller, A., Epstein, S., Goldberg, A., Clardy, J., Lewis, K. Lassomycin, a ribosomally synthesized peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem. Biol. 2014, 21, 509-518. *The first and second authors contributed equally to this work.

  8. Lohans, C. T., van Belkum, M. J., Cochrane, S. A., Huang, Z., Sit, C. S., McMullen, L. M., Vederas, J. C. Biochemical, structural, and genetic characterization of tridecaptin A1, an antagonist of Campylobacter jejuni. ChemBioChem 2014, 15, 243-249.

  9. Lohans, C. T., Huang, Z., van Belkum, M. J., Giroud, M., Sit, C. S., Steels, E. M., Zheng, J., Whittal, R. M., McMullen, L. M., Vederas, J. C. Structural characterization of the highly cyclized lantibiotic paenicidin A via a partial desulfurization/reduction strategy. J. Am. Chem. Soc. 2012, 134, 19540-19543.

  10. Lama, A., Pane-Farre, J., Chon, T., Wiersma, A. M., Sit, C. S., Vederas, J. C., Hecker, M., Nakano, N. M. Response of methicillin-resistant Staphylococcus aureus to amicoumacin A. PLoS One 2012, 7, e34037.

  11. Sit, C. S., Lohans, C. T., van Belkum, M. J., Campbell, C. D., Miskolzie, M., Vederas, J. C. Substitution of a conserved disulfide in the type IIa bacteriocin, Leucocin A, with l-leucine and l-serine residues: effects on activity and three-dimensional structure. ChemBioChem 2012, 13, 35-38.

  12. Sit, C. S., van Belkum, M. J., McKay, R. T., Worobo, R. W., Vederas, J. C. The 3D solution structure of thurincin H, a bacteriocin with four sulfur to alpha-carbon crosslinks. Angew. Chem.Int. Ed. 2011, 50, 8718-8721.

  13. Sit, C. S., McKay, R. T., Hill, C., Ross, R. P., Vederas, J. C. The 3D structure of thuricin CD, a two-component bacteriocin with cysteine sulfur to a-carbon cross-links. J. Am. Chem. Soc. 2011, 133, 7680-7683.

  14. Sit, C. S., Yoganathan, S., Vederas, J. C. Biosynthesis of aminovinyl-cysteine containing peptides and its application in the production of potential drug candidates. Acc. Chem. Res. 2011, 44, 261-268.

  15. Yoganathan, S., Sit, C. S., Vederas, J. C. Chemical synthesis and biological evaluation of gallidermin-siderophore conjugates. Org. Biomol. Chem. 2011, 9, 2133-2141.

  16. Martin-Visscher, L. A., Yoganathan, S., Sit, C. S., Lohans, C., Vederas, J. C. The activity of bacteriocins from Carnobacterium maltaromaticum against Gram-negative bacteria in combination with EDTA treatment. FEMS Microbiol. Lett. 2011, 317, 152-159.

  17. *Rea, M. C., *Sit, C. S., Clayton, E., O’Connor, P. M., Whittal, R. M., Zheng, J., Vederas, J. C., Ross, R. P., Hill, C. Thuricin CD, a post-translationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 9352-9357. *The first and second authors contributed equally to this work.

  18. Huang, T., Geng, H., Miyyapuram, V. R., Sit, C. S., Vederas, J. C., Nakano, M. M. Isolation of a variant of subtilosin A with haemolytic activity. J. Bacteriol. 2009, 191, 5690-5696.

  19. Sit, C. S., Vederas, J. C. Approaches to the discovery of new antibacterial agents based on bacteriocins. Biochem. Cell Biol. 2008, 86, 116-123.

  20. Oyedotun, K. S., Sit, C. S., Lemire, B. D. The Saccharomyces cerevisiae succinate dehydrogenase does not require heme for ubiquinone reduction. BBA Bioenergetics 2007, 1767, 1436-1445.